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Abstract

It is possible that clinical medication evaluations may be more cost-effective if they were directed toward older patients who shared predicted variables for drug-related disorders (DRPs). The purpose of this research was to determine the frequency of DRPs, the types of DRPs, and the possible predicting variables for DRPs in elderly patients who were taking several medications. The methods consisted of community pharmacists doing clinical medication reviews and documenting DRPs, several kinds of treatments, and the implementation of these interventions in older patients. Out of the three hundred eighty-eight medication reviews that were examined, a total of 964 diabetes-related problems (DRPs) with an average of 2.5 ± 1.9 and 1022 interventions with an average of 2.6 ± 2.0 were found. The total implementation rate of treatments was identified as 70.1%, with the greatest rate being found in interventions that were designed to address the issue of inadequate therapy monitoring (86.8%). Patients who were taking at least 12 drugs had a higher probability of having at least 5 DRPs (P <.001).

An association was found between asthma and a lack of adherence (P =.002), as well as a lack of usage of aspirin, statins, and proton pump inhibitors, with extra medication being required (P =.002‐.004) that was required. Antihypertensive drugs and/or pharmaceuticals with narrow therapeutic index were shown to be predictive variables for drug interactions according to statistical analysis (P <.05). Having diabetes was shown to be related with a lack of effectiveness (P =.006). There was a significant correlation between the use of nonsteroidal anti-inflammatory medicines and the selection of unsuitable drugs (P =.002). There was a significant correlation between the absence of monitoring and hypertension (P =.013). On the other hand, the misuse of benzodiazepines (P <.001) and aspirin (P =.021) was seen. It was shown that patients who did not use statins, antithrombotic agents, or proton pump inhibitors were related with increased risks for DRPs. Patients who had asthma, hypertension, and diabetes were also associated with higher risks.

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Section
Review