The goal was to make, test, and improve fast-dissolving films (FDFs) for delivering chlorpromazine via the mouth. The distribution of drugs via the oro-buccal mucosa is quite fascinating, but there weren't many items on the market that could do this. We made FDFs of chlorpromazine using the solvent casting process and the polymers PVA, HPMCE-5, and HPMCE-15. We then tested them for film-specific properties. In vitro and ex vivo dissolution or drug permeation studies were also used to test FDFs for dissolution and percentage drug release. The films DPF1, DHF2, DHF3, DHPF4, and DHPF5 that were made had smooth surfaces with no bubbles or cracks. They were flexible and not sticky, and their weight was consistent, with no notable changes. The pH of the surface was about neutral, the folding endurance stayed the same, and the drug content varied by 84–95%mg. DPF1 was thinner than DHF2, DHF3, DHPF4, and DHPF5. DPF1 has great flexibility and broke down in a shorter amount of time. All formulations of chlorpromazine released it quickly in vitro, with DPF1 showing the highest release rate of 97.2% over 150 seconds. Chlorpromazine was released ex vivo from DPF1 at a substantially faster rate, with a release rate of 85.10% over 150 seconds. The produced FDFs of chlorpromazine conformed to the specified range of film-specific characteristics and complied with it. FDF of chlorpromazine made with the polymer PVA is superior than other films made with other polymers for delivering chlorpromazine to the mouth for the treatment of either psychosis or vomiting.