Researchers have spent a lot of time and effort in the last few decades creating novel drugs. Because of this, there are now a lot of pharmacological compounds that can be utilized to treat a lot of disorders that are an issue for the healthcare system. More than half of these drugs are in the BCS (Biopharmaceutical Classification System) class II/IV, which means that they don't have much therapeutic value and aren't being explored any further. It has been demonstrated that lipoidal production is an effective method for distributing these types of medications. This means that a procedure that uses nanotechnology could be very useful. Nanoemulgel, a gel made up of several nano-lipoidal compositions, has been found to be a good way to apply medications to the skin. Nanoemulgel is a topical gel made from an emulsion. To make nanoemulgel, the right gelling agent is applied to emulsion globules generated with either high-energy or low-energy methods. You can make nanoemulgels from of many kinds of polymers, surfactants, and lipids that are between 5 and 500 nm in size. There are a lot of topical therapies for both short-term and long-term disorders with nanoemulgel. The broad usage of nanoemulgel formulations of recently patented medications in a range of healthcare settings has once again proved that topical administration is better than alternative approaches. Toxicological investigations of the compounds utilized in these formulations must consider their safety, given the significant changes in their administration.