Antibacterial medications have long been vital in the treatment of many illnesses, but overuse causes toxicity and resistance, which is a major problem in the medical field. Globalization, self-medication, excessive and repetitive use of antibiotics, ongoing use of broad-spectrum agents, and a lack of efficient antimicrobial agents are the main causes of the spread of antibiotic resistance. Antibiotics' growing resistance to numerous microbes poses a risk to their continued use in therapy, or an elevated dosage could be harmful. Additionally, it is anticipated and determined that there is an urgent need to find and develop an alternative effective approach for treating antibiotic-resistant patients if no new antibiotics or antibacterial medications are identified in the current circumstances. When applied to resistant microbes, green manufactured nanoparticles are the most efficient, environmentally benign, and effective. In order to provide a promising and efficient remedy for the recurring development of antibiotic resistance by diverse bacterial strains, the current review aims to summarize the mechanisms, classifications, limitations, and uses of various nanotherapeutics nano formulations.