A national public health problem is antimicrobial resistance. Antimicrobials like sulfamethoxazole/ trimethoprim and fluoroquinolones, which are often used to treat infections including cellulitis, urinary tract infections, and upper respiratory infections, have become more resistant as a result of their misuse. Both patients who are ambulatory and those who need to be admitted to the hospital often get these illnesses in the emergency department (ED). The emergency department is in a unique position to influence patterns of antibiotic usage and resistance in both inpatient and ambulatory settings. However, there are several obstacles to overcome when putting antimicrobial stewardship strategies into practice in the emergency department. These include ambiguity about the diagnosis, diversions from patient or staff turnover, and issues with patient satisfaction, to mention a few. Nonetheless, this review paper identifies effective strategies that have reduced the overuse of antibiotics in emergency departments and call for further research. Other, as-yet-unvalidated suggestions are also made in this article. Lastly, this study is a call to action for pharmacists who work in emergency medical settings and in antimicrobial stewardship initiatives. In order to minimize patient damage and stop the emergence of antibiotic resistance, further study is required on the use of these and other treatments to decrease improper antimicrobial usage.