This research seeks to emphasize Type-1 DM, including its genesis, pathophysiology, and treatment in this review. Diabetes is regarded as a chronic condition characterized by hypoglycemia resulting from the dual deficiency of insulin activity and secretion. Type 1 diabetes is also caused by the immune system attacking the cells in the islets of the pancreas. The confrontation to insulin or secretion of insulin lacking due to changes in living standards, habit change, dearth of exercise along with aging also, but one of the most relevant and prevalent reasons is a lifestyle change and also change in food habits along with the stress of the day-to-day life. Stem cell therapy is a costly treatment, and acquiring stem cells is challenging due to ethical concerns and limited availability. Insulin supply therapy is currently available for type-1 diabetes, although it comes with a lot of problems. Advanced substitutes, such as islets, have shown successful outcomes in restoring glucose levels. Additionally, severe type 1-DMM is limited by its high cost, lack of economic processes, and shortage of donors. The replacement of beta-like cells derived from the development of human pluripotent stem cells (hPSCs) yielded outstanding results and garnered significant attention; nonetheless, in stem cell treatment, the acquisition of beta cells alongside full insulin production is crucial.