Goal One of the main causes of disability in the globe is depression. Research indicates that productivity loss is by far the biggest factor contributing to the total economic burden of depression; nevertheless, little is known about the costs of depression outside of high-income Western nations. Therefore, this research looks at how depression affects job productivity in eight different nations. Techniques In eight countries—Brazil, Canada, China, Japan, South Korea, Mexico, South Africa, and the United States—we calculated the prevalence and expenses of presenteeism and absenteeism in the workplace caused by depression. We also looked at the organizational, social, and individual variables linked to decreased productivity. Findings To the best of our knowledge, this is the first research to look at how depression affects workplace productivity in terms of GDP and culture across a wide range of nations. South Korea had the lowest mean annual absence expenses per person at $181, while Japan had the most at $274. Brazil ($5788) and the United States ($5524) had the highest mean presentism expenses per person. The costs of presenteeism were typically five to ten times greater than those of absenteeism. Conclusions According to these statistics, depression has a significant effect on the workplace in every nation, both in terms of absolute money and as a percentage of GDP. All things considered, depression is a problem that needs much more attention, irrespective of a nation's level of economic growth, national wealth, or culture.