The revolutionary role that pharmacists play in incorporating pharmacogenomics into clinical practice is examined in this research. The study of genetic influences on drug response, or pharmacogenomics, offers a previously unheard-of chance to customize pharmaceutical administration. From administering medications, the pharmacist's job has changed to include analyzing and using genomic data to maximize therapeutic results. We explore the historical turning points, clinical applications, and fundamentals of pharmacogenomics. Interpreting genetic data, working with medical professionals, counseling patients, and incorporating pharmacogenomics into medication therapy management are all part of the pharmacist's duties. To guarantee acceptable genomic practice, obstacles including ethical issues and legal frameworks are overcome. With suggestions to improve genetic literacy through extensive educational activities, education stands forth as a pillar. Informed permission, privacy protections, and fair access to pharmacogenomic data are all crucial, according to ethical considerations. Pharmacogenomics in pharmacy practice will only advance with interdisciplinary cooperation, ongoing education, and ethical observance, making pharmacists essential players in the field of personalized medicine.